Rebooting Cancer Tissue Handling in the Sequencing Era - Toward Routine Use of Frozen Tumor Tissue



Laura Goetz, M.D., M.P.H., of the Scripps Translational Science Institute, La Jolla, Calif., and colleagues examine the relevant issues behind the incorporation of optimal tissue sampling techniques into routine pathologic practice and make recommendations for the cancer genomic medicine of the future.

“Moving the pathology and oncology communities toward a new practice incorporating larger tissue samples and the routine use of frozen tissue represents a formidable but attainable change, one that will undoubtedly involve patients' preferences and consent. How quickly a new practice should emerge depends on clinical studies indicating improved patient outcomes associated with detailed genetic evaluation. As genomic testing becomes part of routine care and patients become increasingly informed, medicine will have to adapt to meet the demands of the next generation of patients with cancer, now informed about sequencing options for their particular malignancy.”

(JAMA. 2013;309[1]:37-38.