- Diabetes and Cognition
Diabetes and Cognition
Mild cognitive impairment is a transitional stage between normal aging and dementia, according to background information in the article. Previous studies have found an association between mild cognitive impairment and diabetes.
Poor blood glucose control over time may lead to neuron loss, and diabetes is associated with cardiovascular disease risk and stroke, which also may increase the risk of cognitive impairment.
Rosebud O. Roberts, M.B.Ch.B., M.S., and colleagues at Mayo Clinic, Rochester, Minn., studied individuals from Olmsted County, Minnesota, who were age 70 to 89 on Oct. 1, 2004.
Participants received a neurological examination, neuropsychological evaluation and tests of blood glucose levels, and completed an interview with questions about diabetes history, treatment and complications. A medical records linkage system was used to confirm diabetes history.
Rates of diabetes were similar among 329 individuals with mild cognitive impairment (20.1 percent) and 1,640 participants without mild cognitive impairment (17.7 percent). However, mild cognitive impairment was associated with developing diabetes before age 65, having diabetes for 10 years or longer, being treated with insulin and having diabetes complications.
“Severe diabetes mellitus is more likely to be associated with chronic hyperglycemia [high blood glucose], which, in turn, increases the likelihood of cerebral microvascular disease and may contribute to neuronal damage, brain atrophy and cognitive impairment,” the authors write.
That individuals with the eye disease diabetic retinopathy were twice as likely to have mild cognitive impairment supports the theory that diabetes-related damage to blood vessels in the brain may contribute to the development of cognitive problems.
“Our findings suggest that diabetes mellitus duration and severity, as measured by type of treatment and the presence of diabetes mellitus complications, may be important in the pathogenesis of cognitive impairment in subjects with diabetes mellitus,” they conclude.
“In contrast, late onset of diabetes mellitus, short duration of diabetes mellitus or well-controlled diabetes mellitus may have a lesser effect.”
Arch Neurol. 2008;65:1066-1073.
DISCLAIMER: Bankix Systems Ltd is the registered name of a Canadian firm since 2003, and bankixsystems.com is its OFFICIAL website. Besides these entities, we have no relationship with anyone, business, website, or any other entity anywhere in the world, claiming to be Bankix Systems, or using a similar name, and creating the impression that it has some connection with our company. We do not endorse and are therefore, not responsible for any act or lack thereof by any such entity. Bankix Systems Ltd is also not responsible for the content of the description of products and services linked to our site nor does it necessarily endorse them. The information here provided is not for diagnosing/treating your health concerns. Kindly contact your doctor or health care professional for all your healthcare requirements.
Contents © 2003-2018, BankixSystems.com. All rights reserved. Unauthorized reproduction strictly prohibited. Information based on best available resources. Opinions are current and subject to change.