Older men who take loop diuretics, commonly prescribed drugs for heart failure and hypertension, appear to have increased rates of hip bone loss than men who are not taking this medication, according to a report in the April 14 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Lionel S. Lim, M.D., M.P.H., of
A total of 84 men continuously used loop diuretics between the two time periods, 181 used them intermittently and 3,004 did not use them. After adjusting for other related factors, the average annual rate of decline in total hip bone mineral density was -0.33 percent in non-users, -0.58 percent in intermittent users and -0.78 percent among continuous users.
“Compared with rates of hip bone loss among non-users of diuretics, adjusted rates of loss were about two-fold greater among intermittent loop diuretic users and about 2.5-fold greater among continuous loop diuretic users,” the authors write. Findings were similar at the subregions of the hip.
“We conclude that loop diuretic use in older men in associated with increased rates of hip bone loss,” the authors write. Future research should address the underlying mechanisms, they note. “Our findings suggest that health care providers should take into account loop diuretic use when evaluating older men for risk factors for bone loss and fracture risk.”
Arch Intern Med. 2008; 168:735-740.