Study Examines Subsequent Flu Vaccine Effectiveness in Children Previously Vaccinated

Bottom Line: Influenza vaccination one year wasn’t associated with reduced vaccine effectiveness the next year in children, findings the authors of this study say support current recommendations for children to be vaccinated annually against influenza. The effects of prior-season influenza vaccination on subsequent vaccine effectiveness aren’t well understood in children. This study analyzed data from a vaccine effectiveness study conducted over three seasons that examined the association of prior-season vaccination with vaccine effectiveness and the risk of influenza among vaccinated children between the ages of 2 and 17 by the vaccine type they received. While influenza vaccine effectiveness varied by influenza type and subtype and vaccine type, prior-season vaccination wasn’t associated with reduced vaccine effectiveness.

Authors:  Huong Q. McLean, Ph.D., M.P.H., Marshfield Clinic Research Institute, Marshfield, Wisconsin, and co-authors

Related Material: The invited commentary, “Repeated Vaccination May Protect Children From Influenza Infection,” by Sarah Cobey, Ph.D., University of Chicago, also is available on the For The Media website.

Visual Abstract:

 

To Learn More: The full study is available on the For The Media website.

(doi:10.1001/jamanetworkopen.2018.3742)